Toxicological Sciences publishes research articles that are broadly relevant to assessing the potential adverse health effects resulting from exposure of human or animals to chemicals drugs natural products or synthetic materials. Manuscripts are published in all areas of toxicology both descriptive and mechanistic as well as interpretive or theoretical investigations that elucidate the risk assessment implications of exposure to toxic agents alone or in combination. Studies may involve experimental animals or human subjects or they may focus on in vitro methods or alternatives to the use of experimental animals. Presenting Articles on Toxicologic studies which are structural biochemical or functional in nature Investigations of the effects of dose route of exposure metabolism or species on toxic responses Statistical or mechanism-based approaches to risk assessment. New methods in toxicology. Featured Sections Original research articles short communications Symposium summaries Workshop or Roundtable summaries Reviews Commentaries Research Areas Include Biochemical toxicology pharmacokinetics pharmacodynamics Reproductive and developmental toxicology carcinogenesis Immunotoxicology neurotoxicology pulmonary toxicology In vitro methods alternatives to experimental animals Safety evaluation risk assessment.

毒理學(xué)發(fā)表的研究文章與評估人類或動(dòng)物接觸化學(xué)藥物、天然產(chǎn)品或合成材料可能對健康造成的不利影響有著廣泛的相關(guān)性。在毒理學(xué)的所有領(lǐng)域，無論是描述性的還是機(jī)械性的，以及解釋性的或理論性的調(diào)查中都發(fā)表了手稿，闡明了單獨(dú)或結(jié)合接觸有毒物質(zhì)的風(fēng)險(xiǎn)評估影響。研究可能涉及實(shí)驗(yàn)動(dòng)物或人類實(shí)驗(yàn)對象，也可能側(cè)重于體外方法或?qū)嶒?yàn)動(dòng)物使用的替代方法。發(fā)表毒理研究的文章，這些毒理研究屬于結(jié)構(gòu)性生化或功能性研究，研究暴露代謝或物種的劑量路線對毒性反應(yīng)的影響，統(tǒng)計(jì)或基于機(jī)制的風(fēng)險(xiǎn)評估方法。毒物學(xué)的新方法。主要研究章節(jié)原始文章短通訊研討會摘要研討會或圓桌總結(jié)評論評論領(lǐng)域包括生化毒物學(xué)藥物動(dòng)力學(xué)藥物動(dòng)力學(xué)生殖和發(fā)育毒物學(xué)致癌免疫毒物學(xué)神經(jīng)毒物學(xué)肺毒物學(xué)實(shí)驗(yàn)動(dòng)物安全評價(jià)風(fēng)險(xiǎn)評估的替代方法。