The journal focuses on the aetiology and pathogenesis of demyelinating and inflammatory diseases of the central nervous system and on the application of such studies to scientifically based therapy. The following research areas are of particular interest to the journal: Clinical neurology Myelin chemistry Neuroimaging Pathobiology of the blood/brain barrier Glial pathobiology/myelin repair Pathology Epidemiology Therapeutics Genetics Immunology Virology Psychology Rehabilitation.

該雜志側重于中樞神經系統脫髓鞘和炎癥性疾病的病因學和發病機制，以及將這些研究應用于科學的治療。臨床神經學、髓鞘化學、神經影像學、病理生物學、血腦屏障、神經膠質病理生物學、髓鞘修復、病理學、流行病學、治療學、遺傳學、免疫學、病毒學、心理學、康復學等方面的研究是本雜志特別感興趣的領域。